It all seemed like a fairy tale when childhood sweethearts Sabrina and Andrew finally got married and blessed with a daughter and son. Their relationship became irretrievably broken when Andrew moved to Mainland China for business and had an affair, leading to their eventual divorce. Years later, Andrew became very ill. Sabrina returned to her ex-husband's side without hesitation and accompanied Andrew on his last journey.

青梅竹馬的靜芬（葉童 飾）和麒振（謝君豪 飾），經歷天各一方、兩地相思後，終成眷屬，育有一女一子。本是個幸福的結局，可是命運再次考驗二人的感情。夫妻二人再度分居兩地，自各在自己的生活中承受著現實所帶來的衝擊，後來麒振的身邊更出現了第三者，導致婚姻破裂。可是靜芬卻沒有放棄對麒振的感情，在無法得到親人的體諒之下，咬緊牙關照顧一對子女成長，並期朌麒振有一天會浪子回頭。多年之後，麒振病入膏肓，靜芬不計前嫌回到前夫的身邊，源自於她一直所堅守的信念：真愛，一生人只有一次。